Jean A Monro, MB BS MRCS LRCP FAAEM DIBEM MACOEM Medical Director, Breakspear Hospital, England
ABSTRACT

CYTOKINE TH1 TO TH2 SHIFT CAN BE REVERSED BY CORIOLUS. PROSPECTIVE TRIAL FOR HPV CONTROL WITH CORIOLUS

Infection by Human Papillomavirus (HPV) can induce cervical cancer. There is evidence for correction of immune responses in patients with chronic fatigue syndrome and persistent viral infection with Coriolus.

The defects and abnormal immune responses seen in patients with chronic fatigue syndrome have been treated with Coriolus. A group of 60 patients have had the diagnosis of chronic fatigue syndrome established by national diagnostic criteria.

We have shown in these patients there are abnormal T-lymphocyte subsets and low natural killer cells. We have established that, in these patients, many of them have activation of Epstein Barr virus, Cytomegalovirus or Human Herpes virus 6, and high titres of antibodies, IgG or IgM, to these viruses. In treatment of these patients with Coriolus for an eight week programme, there was a doubling of the levels of natural killer cells.

It is therefore suggested that cancer risk from Human Papillomavirus can be minimised by augmentation of immunological parameters. Those at risk, having contracted HPV as evaluated by PCR techniques, can then be protected with Coriolus as a preventive cancer programme, so that the cervical cancer may not then subsequently develop. In our experience, folic acid has also been of benefit. Postulation that nutritional, microbiological and immune biomarkers can be evaluated and the synergistic use of Coriolus and folic acid could be used preventatively for cervical cancer.

References:
Bosch, FX et al. Papillomavirus research update: highlights of the Barcelona HPV 2000 international papillomavirus conference. J Clin Pathol 2001;54:163-175.
Butterworth, CE Jr et al. Oral folic acid supplementation for cervical dysplasia: a clinical intervention trial. Am J Obsted Gynecol 1992 Mar;166(3):803-9.
Butterworth, CE Jr et al. Folate deficiency and cervical dysplasia. JAMA 1992 Jan 22-29;267(4):528-33.
Kwasniewska A et al. Folate deficiency and cervical intraepithelial neoplasia. Eur J Gynaecol Oncol 1997;18(6):526-30.